Drug repurposing against SARS-CoV-2: A review based on principal reports

Despite the measures taken and the molecular advances for the development of new agents for the control of SARS-CoV-2 infection, there is still insufficient development of an effective treatment. The objective of the review was to de-scribe the clinical studies and reported articles on drugs used as possible therapeutic agents for COVID-19 and the main conclusions on their reuse. A non-systematic review through PubMed, ScienceDirect, and clinical trials at ClinicalTrials. gov on original articles and case report in English and Span-ish that will report information on COVID-19 treatment and its main conclusions. Articles that were not relevant or that did not mention updated information to that reported in other articles were excluded. A total of 99 bibliographic references were included. COVID-19 appears as a multisystemic disease with variable clinical symptoms. Since no specific treatment is yet known, multiple drugs have been proposed that attack the different pathways of SARS-CoV-2. For severe disease in patients who require hospitalization and oxygen support, the use of remdesivir, dexamethasone, or tocilizumab is recommended if there are patient conditions that apply to use them. The use of ivermectin, colchicine, lopinavir/ritonavir, hydroxy-chloroquine, and chloroquine have not reported benefits that surpass adverse effects.

Drug repurposing against SARS-CoV-2: A review based on principal reports

Despite the measures taken and the molecular advances for the development of new agents for the control of SARS-CoV-2 infection, there is still insufficient development of an effective treatment. The objective of the review was to de-scribe the clinical studies and reported articles on drugs used as possible therapeutic agents for COVID-19 and the main conclusions on their reuse. A non-systematic review through PubMed, ScienceDirect, and clinical trials at ClinicalTrials. gov on original articles and case report in English and Span-ish that will report information on COVID-19 treatment and its main conclusions. Articles that were not relevant or that did not mention updated information to that reported in other articles were excluded. A total of 99 bibliographic references were included. COVID-19 appears as a multisystemic disease with variable clinical symptoms. Since no specific treatment is yet known, multiple drugs have been proposed that attack the different pathways of SARS-CoV-2. For severe disease in patients who require hospitalization and oxygen support, the use of remdesivir, dexamethasone, or tocilizumab is recommended if there are patient conditions that apply to use them. The use of ivermectin, colchicine, lopinavir/ritonavir, hydroxy-chloroquine, and chloroquine have not reported benefits that surpass adverse effects. Copyright © 2022, Venezuelan Society of Pharmacology and Clinical and Therapeutic Pharmacology. All rights reserved.

EE-7978. Implementación de la campaña de vacunación frente a COVID-19 en un hospital de tercer nivel

Gestionar la campaña de vacunación COVID-19 siguiendo las recomendaciones vigentes de las autoridades sanitarias nacionales y autonómicas en un hospital de tercer nivel. Métodos: Se formó el Comité de Vacunación_COVID-19 del hospital (Direcciones: Médica, Enfermería y Planificación;Servicios: Medicina Preventiva, Farmacia, Admisión, Pediatría). Reuniones semanales. Se organizó: a) diseño/implementación de circuitos de vacunación;b) gestión de citas;c) gestión de recursos;d) cuadro de mando. Resultados: Inicialmente se organizaron 2 circuitos de vacunación: los pacientes con condiciones de alto riesgo (inicio de vacunación: 12/04/2021) y población en general (ciudadanos por grupo de edad) (inicio de vacunación: 10/04/2021). La Unidad de Vacunación-Servicio de Medicina Preventiva (UV-MPRE) participa activamente en la coordinación del proceso y se encarga de la elaboración de cartelería (preparación de vacunas ARNm, según ficha técnica;la elaboración del procedimiento de trabajo: FEA de guardia en los circuitos;el registro normalizado de uso de viales/incidencias y coordinación de guardias FEA en ambos circuitos de vacunación). En 2021, se realizaron 231 turnos de vacunación entre los 2 circuitos. En una segunda etapa se organizó la vacunación COVID-19 de los pacientes de alto riesgo y las dosis de recuerdo según las recomendaciones vigentes mediante la citación en UV-MPRE (parte de interconsulta);(2021: se vacunaron 1.937 pacientes en UV-MPRE). Para la gestión de los pacientes citados en UV-MPRE, se crearon 5 agendas con prestaciones específicas (según el número de dosis y la marca comercial, inicialmente para una pauta homóloga) (tabla 1). Para el seguimiento/cumplimiento de la pauta vacunal de los pacientes vacunados UV-MPRE se creó en la historia clínica electrónica el proceso: COVID19-vacunación y un localizador de pacientes con vacunación COVID-19 incompleta (2021: 3.741 procesos: COVID19-Vacunación). La UV-MPRE también se encarga de: registrar vacunas administradas en el Registro Unificado de Vacunación (RUV);resolver las incidencias en el RUV a requerimiento de los interesados;resolver dudas relacionadas con las vacunas COVID-19 y la estrategia de vacunación;la emisión del certificado COVID-19 digital-UE (vacunación/recuperación): 1.127 durante 2021.Unlabelled Image Conclusiones: La participación del hospital en el despliegue de la estrategia de vacunación COVID-19 y el abordaje multidisciplinario en su organización, ha permitido una mejor adaptación al contexto, integrar la gestión de riesgos, una buena coordinación interprofesional logrando una mayor eficiencia en los resultados y la calidad en la atención al paciente.

Preventive strategies in the components of the ecological triad against covid-19

Introduction: Each communicable disease, in accordance with its main transmission mechanism, is controlled by certain measures directed to the elements of the ecological triad: elimination of the reservoir, interruption of the mode of transmission and protection of the susceptible organism. Objective: Examine some preventive strategies in the components of the ecological triad against COVID-19. Methods: Bibliographic review of scientific articles in English and Spanish, available in databases like PubMed, Scopus, Medline, SciELO, and in the Google Scholar search engine, in addition to exploring websites of ministries of health, WHO, PAHO, Infomed, and other national and international sources. The quality, reliability and validity of the selected items were analyzed. 71 articles were studied, of which 52 were referenced. Results: The main elements that make up COVID-19 prevention and control measures directed to the elements of the ecological triad are described, among the multitude of available information in the confrontation with this health problem. Final considerations: In-depth knowledge of the relationships between the host, the pathogen and the environment jointly with its ecology is crucial to counteract infectious pathogens, where prevention plays a fundamental and primary role. Compliance with control measures at each link in the ecological triad is vital to prevent the spread of this disease. © 2021, Editorial Ciencias Medicas. All rights reserved.

Universities and communication: role of Twitter during the beginning of the Covid-19 health crisis

The crisis resulting from the Covid-19 pandemic has affected (among other organizations) universities, because their usual activities have been modified. Social networks, in particular Twitter, have experienced an increase in use. The aim of this research is to analyze the behavior of Spanish universities on Twitter during the period between 1 January and 30 April 2020. The corporate accounts of all Spanish universities were monitored, the most relevant key performance indicators (KPIs: commitment, followers, tweets, favorites, and retweets) were analyzed, and finally, a sentiment analysis of the tweets with the greatest impact was carried out. In addition, this study proposes the ECCD model (educational, cooperative, corporate and informative), which is capable of categorizing the type of information issued by universities in crisis situations. This article shows the relevance of Twitter as a communication channel in critical situations, as well as the increased commitment of the digital community to university accounts. It also demonstrates how the positive polarity of messages issued by privately owned universities increases in crisis situations. Finally, this article highlights different behavior between the pre-Covid-19 compared with the pandemic stage.